Simplest method is to mix entire 10ml bottle into a 2L Soda bottle of 1:1 sugar syrup. This is enough for 10 treatments. Each treatment should be around 3/4 cup of mixed syrup. Each hive should be treated 2x in Spring 10 days apart, and then again 2x in Fall 10 days apart. For a single hive treatment, mix 20 drops of Nozevit+ in 3/4 cup of 1:1 sugar syrup.
Research has shown drizzle method has the highest effect against Nosema. Drizzling as shown in the video below. Nozevit+ should be kept refrigerated.